We are interested in linking components that bridge length scales in tendon, including GAGs, elastic fibers, and enzymatic collagen crosslinks.
GAG Amounts
Normalized GAG amounts in SST samples treated for 6 h with different concentrations of ChABC buffer
Histology
Typical histological images of paired control and treated SST samples, which were stained by H&E and Alcian blue to show collagenous ECM ((a)–(c)) and GAGs ((d)–(i)), respectively.
Microscopy images
Microscopy images from three locations of the same sample before and after application of 0.24 shear strain.
Publications
3. Eekhoff JD, Fang, F, Lake SP: Multiscale mechanical effects of collagen cross-linking in tendon. Connective Tissue Research, Invited for special issue: “Multiscale Molecular Interactions of Tendon”, 59(5):410-422,2018. [PubMed]
2. Eekhoff J, Fang F, Kahan LG, Espinosa MG, Cocciolone A, Wagenseil JE, Mecham RP, Lake SP: Functionally distinct tendons from elastin haploinsufficient mice exhibit mild stiffening and tendon-specific structural alteration. Invited for special issue: “Spotlight on the Future of Musculoskeletal Biomechanics.” Journal of Biomechanical Engineering, 139(11):111003, 2017. [PubMed]
1. Fang F, Lake SP: Multiscale mechanical evaluation of human supraspinatus tendon under shear loading after glycosaminoglycan reduction. Journal of Biomechanical Engineering, 139(7):071013, 2017. [PubMed]