In Progress
94. Castile RM, Jobe J, Iannucci LE, Reals RF, Pavey SN, Fitzgerald J, Lake SP: Building a partnership between a university and local high school to foster and grow interest in biomedical sciences and engineering. Journal of Biomechanical Engineering, In press.
93. Bodmer N, Knutsen R, Roth R, Castile R, Brodt M, Gierasch C, Broekelmann T, Gibson M, Haspel J, Lake S, Brody S, Silva M, Mecham R, Ornitz D: Multi-organ phenotypes in mice lacking Latent TGFβ Binding Protein 2 (LTBP2). Developmental Dynamics, In press.
2023
92. Lake SP, Snedeker JG, Wang VM, Awad HA, Screen HR, Thomopoulos S: Guidelines for ex vivo mechanical testing of tendon. Journal of Orthopaedic Research, 41(10):2105-2113, 2023.
91. Lake SP, Bradbury K, Gagne D, Deeken CR, Badhwar A, Bohnen A: Efficacy of flowable collagen hemostat evaluated in preclinical models of liver injury and spinal cord exposure. Medical Devices: Evidence and Research, 16:123-132, 2023
90. Iannucci LE, Riak MB, Meitz E, Bersi MR, Gruev V, Lake SP: The effect of matrix properties on transmission and reflectance mode division-of-focal-plane Stokes polarimetry. Journal of Biomedical Optics, 28(10):102902, 2023.
89. Lane RA, Migotsky N, Havlioglu N, Iannucci LE, Shen H, Lake SP, Sakiyama-Elbert SE, Thomopoulos S, Gelberman RH: The effects of NF-kB suppression on the early healing response following intrasynovial tendon repair in a canine model. Journal of Orthopaedic Research, 41(10):2295-2304, 2023.
88. Easson G, Savadipour A, Anandarajah A, Iannucci LE, Lake SP, Guilak F, Tang S: Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc. FASEB, 37:e22714, 2023.[PubMed]
87. Reiter AJ, Schott HR, Castile RM, Cannon PC, Havlioglu N, Chamberlain AM, Lake SP: Early Joint Use Following Elbow Dislocation Limits Range-of-Motion Loss and Tissue Pathology in Posttraumatic Joint Contracture. The Journal of Bone and Joint Surgery, 105:223-230, 2023. [PubMed]
86. Zellers JA, Edalati M, Eekhoff JD, McNish R, Tang SY, Lake SP, Mueller MJ, Hastings MK, Zheng J: Quantitative MRI predicts tendon mechanical behavior, collagen composition, and organization. Journal of Orthopaedic Research, 41(10):2329-2338, 2023.
85. Iannucci LE, Koscso J, Smith MV, Lake SP: Biomechanical effect of differential tensioning on suture augmented ulnar collateral ligament reconstruction of the elbow. American Journal of Sports Medicine, 51(1):205-213, 2023.[PubMed]
84. Vaidya R, Lake SP, Zellers JA: Effect of diabetes on tendon structure: not limited to collagen crosslinking. Journal of Diabetes Science and Technology, 17(1):89-98, 2023. [PubMed]
83. Eekhoff JD, Abraham JA, Schott HR, Solon LF, Ulloa GE, Zellers JA,Cannon PC, Lake SP: Fascicular elastin within tendon contributes to the magnitude and non-linearity of the elastic stress response across tendon type and species. Acta Biomaterialia, Invited paper for special issue: “The Mechanics of Cells and Fibers”, 163:91-105, 2023. [PubMed]
2022
82. Chang P, Solon LF, Lake SP, Castile RM, Hill JR, Brophy RH:Mechanical and microstructural properties of the meniscal roots vary by location. American Journal of Sports Medicine, 50(10):2733-2739, 2022. [PubMed]
81. Iannucci LE, Dranoff CS, David MA, Lake SP: Optical imaging of dynamic collagen processes in disease and health. Frontiers in Mechanical Engineering (Special Issue: The Mechanobiology of Collagen Remodeling in Health and Disease), 8:855271, 2022 [Journal Website]
80. Obiofuma C, Dy C, Iannucci LE, Lake SP, Brogan D: Increasing dorsal tilt in distal radius fractures does not increase median nerve strain. Plastic and Reconstructive Surgery – Global Open, 10(3):e4177, 2022.[PubMed]
79. David MA, Reiter AJ, Dunham CL, Castile RM, Abraham JA, Iannucci LE, Shah ID, Havlioglu N, Chamberlain AM, Lake SP: Pleiotropic effects of simvastatin and losartan in preclinical models of post-traumatic elbow contracture. Frontiers in Bioengineering & Biotechnology (Special Issue: Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology), 10:2022.[PubMed]
78. Solon LF, Castile RM, Smith MV, Lake SP: Mechanical properties and microstructural organization of common ulnar collateral ligament grafts: palmaris longus and gracilis tendons, Journal of Orthopaedic Research, 40:1865-1871, 2022.[PubMed]
77. Bashir MH, Hollingsworth A, Thompson JD, Shortridge D, Lake SP, Deeken CR, Zimbler D, Mashiatulla M, Li L, Singh MP, Zook EC: Antimicrobial performance of two preoperative skin preparation solutions containing iodine and isopropyl alcohol. American Journal of Infection Control, 50(7):792-798, 2022. [PubMed]
76. Castile RM, Cannon PC, Smith MV, Brophy RH, Lake SP: Donor age and sex have limited effects on the mechanical and microstructural properties of human connective tissues. Journal of Orthopaedic Research, 40:1844-1852, 2022. [PubMed]
2021
75. Zellers JA, Eekhoff JD, Walk R, Hastings MK, Tang SY, Lake SP: Human Achilles tendon mechanical behavior is more strongly related to collagen disruption than advanced glycation end-products content. Scientific Reports, 11:24147, 2021. [PubMed]
74. Reiter AJ, Castile RM, Schott HR, Kivitz GJ, Chamberlain AJ, Lake SP: Investigating the effects of physical therapy timing, intensity and duration on post-traumatic joint contracture in a rat elbow model: a preliminary study. Muscles, Ligaments and Tendons Journal, 11(3):547-553, 2021. [Journal Website]
73. Chen Y, Zhu Z, Liang Z, Iannucci LE, Lake SP, Gruev V: Analysis of signal-to-noise ratio of angle of polarization and degree of polarization. OSA Continuum, 4(5):1461-1472, 2021 [Journal Website]
72. Eekhoff JD, Iannucci LE, Lake SP: Shear mechanosensing drives tendon adaptation. Nature Biomedical Engineering, 5(12):1409-1410, 2021. [PubMed]
71. Reiter AJ, Schott HR, Castile RM, Cannon PC, Havlioglu N, Chamberlain AM, Lake SP: Females and males exhibit similar functional, mechanical and morphological outcomes in a rat model of post-traumatic elbow contracture, Journal of Orthopaedic Research, 39(9), 2062-2072, 2021. [PubMed]
70. Guo J, Simmons DW, Ramahdita G, Munsell MK, Oguntuyo K, Kandalaft B, Rios B, Pear M, Schuftan D, Jiang H, Lake SP, Genin G, Huebsch N: Elastomer grafted iPSC-derived micro heart muscles to investigate effects of mechanical loading on physiology. ACS Biomaterials Science and Engineering, 7(7):2973-2989, 2021. Invited article for special issue. [PubMed]
69. Dunham CL, Steenbock H, Brinckmann J, Reiter AJ, Castile RM, Chamberlain AM, Lake SP: Increased volume and collagen crosslinks drive soft tissue contribution to post-traumatic elbow contracture in an animal model. Journal of Orthopedic Research, 39(8):1800-1810, 2021 [PubMed]
68. Eekhoff JD, Steenbock H, Berke IM, Brinckmann J, Yanagisawa H, Wagenseil JE, Lake SP: Dysregulated assembly of elastic fibers in fibulin-5 knockout mice results in a tendon specific increase in elastic modulus. Journal of Mechanical Behavior of Biomedical Materials, 113, 104134, 2021. [PubMed]
67. Patel R, Castile RM, Lake SP, Brophy RH: Microstructural and mechanical properties of the anterolateral ligament of the knee. American Journal of Sports Medicine, 49(1):172-182, 2021. [PubMed]
66. Lake SP: Emerging trends in elbow injury, pathology and treatment. Annals of Joint, 6:2, 2021. [Journal Website]
65. David MA, Chamberlain AM, Lake SP: Preclinical models of elbow injury and pathology. Annals of Joint, 6:12, 2021.[Journal Website]
2020
64. King NO, Gruev V, Lake SP: The implementation of a logarithmic division-of-focal-plane polarimeter to quantify changes in collagen alignment at varying levels of illumination. Applied Optics,59(26):7813-7820, 2020. [PubMed]
63. Dunham CL, Havlioglu N, Chamberlain AM, Lake SP, Meyer GA: Adipose stem cells exhibit mechanical memory and reduce fibrotic contracture in a rat elbow injury model, FASEB, 34(9):12976-12990, 2020. [PubMed]
62. Eekhoff JD, Lake SP: Three-dimensional computation of fiber orientation, diameter, and branching in segmented image stacks of fibrous networks. Journal of Royal Society Interface, 17(169):20200371, 2020. [PubMed]
61. Castile RM, Jenkins MJ, Lake SP, Brophy RH: Microstructural and mechanical properties of grafts commonly used for cruciate ligament reconstruction. Journal of Bone and Joint Surgery, 102(22):1948-1955, 2020. [PubMed]
60. Hill JR, Eekhoff JD, Brophy RH, Lake SP: Elastic Fibers in orthopedics: form and function in tendons and ligaments, clinical implications, and future directions. Journal of Orthopedic Research, 38(11):2305-2317, 2020 [PubMed]
2019
59. Lake SP, Stoikes NFN, Badhwar A, Deeken CR: Contamination of hybrid hernia meshes compared to bioresorbable PhasixTM Mesh in a rabbit subcutaneous implant inoculation model. Annals of Medicine in Surgery, 46:12-16, 2019. [PubMed]
58. Bernholdt DL, Lake SP, Castile RM, Papangelou C, Hauck O, Smith MV: Biomedical comparison of docking ulnar collateral ligament reconstruction with and without an internal brace. J Shoulder Elbow Surgery. 2019 Jul 24. pii: S1058-2746(19)30331-3: doi: 10.1016/j.jse.2019.04.061 [PubMed]
57. Reiter AJ, Kivitz, GJ, Castile RM, Cannon PC, Mills EH, Jacobs BY, Allen KD, Chamberlain AM, Lake SP: Functional measures of grip strength and gait remain altered long-term in a rat model of post-traumatic elbow contracture. Journal of Biomechanical Engineering, 141(7):071001, 2019.[PubMed]
56. Dunham CL, Castile RM, Chamberlain AM, Lake SP: The role of periarticular soft tissues in persistent motion loss in a rat model of post-traumatic elbow contracture. The Journal of Bone & Joint Surgery, 101(5):e17, 2019. [PubMed]
55. Smith MV, Castile RM, Brophy RH, Dewan A, Bernholt D, Lake SP: Mechanical Properties and Microstructural Collagen Alignment of the Ulnar Collateral Ligament During Dynamic Loading. The American Journal of Sports Medicine. 2019 Jan; 47(1):151-157 [PubMed]
2018
54. Dunham CL, Chamberlain AM, Meyer GA, Lake SP: Muscle does not drive persistent post-traumatic elbow contracture in a rat model. Muscle and Nerve, 58:843-851, 2018 [PubMed]
53. Eekhoff JD, Fang, F, Lake SP: Multiscale mechanical effects of collagen cross-linking in tendon. Connective Tissue Research, Invited for special issue: “Multiscale Molecular Interactions of Tendon”, 59(5):410-422,2018. [PubMed]
52. Dunham CL, Castile RM, Havlioglu N, Chamberlain AM, Lake SP. Temporal Patterns of Motion in Flexion-extension and Pronation-supination in a Rat Model of Posttraumatic Elbow Contracture. Clin Orthop Relat Res. 2018 Sep;476(9):1878-1889[PubMed].
51. Jacobs BY, Lakes EH, Reiter AJ, Lake SP, Ham TR, Leipzig ND, Porvasnik SL, Schmidt CE, Wachs RA, Allen KD: The open source GAITOR suite for preclinical gait analysis. Scientific Reports, 8(1):9797, 2018. [PubMed]
50.Kahan LG, Lake SP, McAllister JM, Tan WH, Yu J, Thompson D Jr, Brunt LM, Blatnik JA. Combined in vivo and ex vivo analysis of mesh mechanics in a porcine hernia model.Surg Endosc. 2018 Feb;32(2):820-830. doi: 10.1007/s00464-017-5749-9. Epub 2017 Jul 21. [PubMed]
2017
49. Eekhoff J, Fang F, Kahan LG, Espinosa MG, Cocciolone A, Wagenseil JE, Mecham RP, Lake SP: Functionally distinct tendons from elastin haploinsufficient mice exhibit mild stiffening and tendon-specific structural alteration. Invited for special issue: “Spotlight on the Future of Musculoskeletal Biomechanics.” Journal of Biomechanical Engineering, 139(11):111003, 2017. [PubMed]
48. Deeken CR, Lake SP: Mechanical properties of the abdominal wall and biomaterials utilized for hernia repair. Journal of Mechanical Behavior of Biomedical Materials, 74:411-427, 2017. [PubMed]
47. Kahan LG, Guertler C, Blatnik JA, Lake SP: Validation of single c-arm fluoroscopic technique for measuring in vivo abdominal wall deformation. Journal of Biomechanical Engineering, 139(8):084502, 2017. [PubMed]
46. Fang F, Lake SP: Experimental evaluation of multiscale tendon mechanics. Journal of Orthopaedic Research, 35(7):1353-1365, 2017. [PubMed]
45. Fang F, Lake SP: Multiscale mechanical evaluation of human supraspinatus tendon under shear loading after glycosaminoglycan reduction. Journal of Biomechanical Engineering, 139(7):071013, 2017. [PubMed]
44. Dunham CL, Castile RM, Chamberlain AM, Galatz LM, Lake SP: Pronation-supination motion is altered in a rat model of post-traumatic elbow contracture. Journal of Biomechanical Engineering, 139(7):071011, 2017. [PubMed]
43. Skelley NW, Lake SP, Brophy RH: Microstructural properties of the anterior cruciate ligament. Annals of Joint, 2:19, 2017. [Journal Website]
42. Dunham CL, Castile RM, Havlioglu N, Chamberlain AM, Galatz LM, Lake SP: Persistent motion loss after free mobilization in a rat model of post-traumatic elbow contracture. Journal of Shoulder and Elbow Surgery, 26(4):611-618, 2017. [PubMed]
41. Est S, Roen M, Chi T, Simien A, Castile RM, Thompson Jr. DM, Blatnik J, Deeken CR, Lake SP: Multi-directional mechanical analysis of synthetic scaffolds for hernia repair. Journal of Mechanical Behavior of Biomedical Materials, 71:43-53, 2017. [PubMed]
40. Cooney GM, Lake SP, Thompson Jr. DM, Castile RM, Winter DC, Simms CK: The suture pullout characteristics of human and porcine line alba. Journal of Mechanical Behavior of Biomedical Materials, 68:103-114, 2017. [PubMed]
2016
39. Skelley NW, Castile RM, Weber CI, Brophy RH, Lake SP: Regional variance in the mechanical and microstructural properties of the human ACL. American Journal of Sports Medicine, 44(11):2892-2899, 2016. [PubMed]
38. Wright JO, Skelley NW, Schur RP, Castile RM, Lake SP, Brophy RH: Microstructural and mechanical properties of the anterolateral and posteromedial bundles of the posterior cruciate ligament. Journal of Bone & Joint Surgery, 98:1656-64, 2016. [PubMed]
37. Lai VK, Nedrelow DS, Lake SP, Kim B, Weiss EM, Tranquillo RT, Barocas VH: Swelling of collagen-hyaluronic acid co-gels: an in vitro residual stress model. Annals of Biomedical Engineering, 44(10):2984-2993, 2016. [PubMed]
36. Shah NS, Beebe DC, Lake SP, Filas BA: On the spatiotemporal material anisotropy of the vitreous body in tension and compression. Annals of Biomedical Engineering, 44(10):3084-3095, 2016. [PubMed]
35. Fang F, Lake SP: Multiscale mechanical integrity of human supraspinatus tendon in shear after elastin depletion. Journal of Mechanical Behavior of Biomedical Materials, 63:443-455, 2016. [PubMed]
34. Cooney GM, Lake SP, Thompson Jr. DM, Castile RM, Winter DC, Simms CK: Uniaxial and biaxial tensile stress-stretch response of human linea alba. Journal of Mechanical Behavior of Biomedical Materials, 63:134-140, 2016. [PubMed]
33. Castile RM, Skelley NW, Babaei B, Brophy RH, Lake SP: Microstructural properties and mechanics vary between bundles of the human anterior cruciate ligament during stress-relaxation. Journal of Biomechanics, 49(1):87-93, 2016. [PubMed]
32. Fang F, Lake SP: Modeling approaches for evaluating multiscale tendon mechanics. Interface Focus, 6:20150044, 2016. [PubMed]
31. Witzenburg CM, Dhume R, Lake SP, Barocas VH: Automatic segmentation of mechanically inhomogeneous tissues based on deformation gradient jump. IEEE Transactions on Medical Imaging, 35(1):29-41, 2016. [PubMed]
30. Lake SP, Castile RM, Borinsky S, Dunham CL, Havlioglu N, Galatz LM: Development and use of an animal model to study post-traumatic stiffness and contracture of the elbow. Journal of Orthopaedic Research, 34(2):354-364, 2016. [PubMed] — Awarded the 2017 Early-Career Award from the Journal of Orthopaedic Research
2015
29. Fang F, Lake SP: Multiscale strain analysis of tendon subjected to shear and compression demonstrates strain attenuation, fiber sliding, and reorganization. Journal of Orthopaedic Research, 33(11):1704-1712, 2015. [PubMed]
28. Skelley NW, Castile RM, York T, Gruev V, Lake SP, Brophy RH: Differences in the microstructural properties of the anteromedial and posterolateral bundles of the anterior cruciate ligament. American Journal of Sports Medicine, 43(4):928-936, 2015. [PubMed]
27. Lake SP, Ray S, Zihni A, Thompson Jr. DM, Gluckstein J, Deeken CR: Pore size and pore shape – but not mesh density – alter the mechanical strength of tissue ingrowth into synthetic mesh materials in a porcine model of ventral hernia repair. Journal of the Mechanical Behavior of Biomedical Materials, 42:186-197, 2015. [PubMed]
2014
26. Filas BA, Shah NS, Zhang Q, Shui Y, Lake SP, Beebe DC: Quantitative imaging of enzymatic vitreolysis-induced fiber remodeling. Investigative Ophthalmology & Visual Science, 55(12):8626-37, 2014. [PubMed]
25. York T, Powell SB, Gao S, Kahan L, Charanya T, Saha D, Roberts NW, Cronin TW, Marshall J, Achilefu S, Lake SP, Raman B,Gruev V: Bio-inspired polarization imaging sensors: from circuits and optics to signal processing algorithms and biomedical applications. Proceedings of IEEE, 102(10):1450-1469, 2014. [PubMed] — Awarded the 2016 IEEE Donald G. Fink Prize Paper Award
24. Fang F, Sawhney AS, Lake SP: Different regions of bovine deep flexor tendon exhibit distinct elastic, but not viscous, mechanical properties under both compression and shear loading. Journal of Biomechanics, 47:2869-2877, 2014. [PubMed]
23. Deeken CR, Thompson Jr. DM, Castile RM, Lake SP: Biaxial analysis of synthetic scaffolds for hernia repair demonstrates variability in mechanical anisotropy, non-linearity and hysteresis. Journal of the Mechanical Behavior of Biomedical Materials, 38C:6-16, 2014. [PubMed]
22. York T, Kahan L, Lake SP, Gruev V: Real-time high-resolution measurement of collagen alignment in dynamically loaded soft tissue. Journal of Biomedical Optics, 19(6):66011, 2014. [PubMed]
21. Adhikari N, Billaud M, Carlson M, Lake SP, Montaniel KRC, Staggs R, Walek D, Isakson BE, Barocas VH, Hall JL: Smooth muscle specific deletion of Ndst1 results in increased arterial elasticity in mice. Molecular and Cellular Biochemistry, 385(1-2):225-38, 2014. [PubMed]
2013
20. Zhang L, Lake SP, Barocas VH, Shepard MS, Picu RC: Cross-linked fiber network embedded in matrix – elastic moduli and internal stresses. Soft Matter, 9:6398-6405, 2013. [PubMed]
19. Zhang L, Lake SP, Lai VK, Picu CR, Barocas VH, Shephard MS: A coupled fiber-matrix model demonstrates highly inhomogeneous microstructural interactions in soft tissues under tensile load. Journal of Biomechanical Engineering, 135(1):011008, 2013.[PubMed]
2012
18. Lai VK, Frey CR, Kerandi AM, Lake SP, Tranquillo RT, Barocas VH: Microstructural and mechanical differences between digested collagen-fibrin co-gels and pure collagen and fibrin gels. Acta Biomaterialia, 8:4031-4042, 2012.[PubMed]
17. Lake SP, Hadi MF, Lai VK, Barocas VH: Mechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gels. Annals of Biomedical Engineering, 40(10):2111-2121, 2012.[PubMed]
16. Lake SP, Barocas VH: Mechanics and kinematics of soft tissue under indentation are determined by the degree of initial collagen fiber alignment. Journal of the Mechanical Behavior of Biomedical Materials, 13:25-35, 2012.[PubMed]
15. Lai VK, Lake SP, Frey CR, Tranquillo RT, Barocas VH: Mechanical behavior of collagen-fibrin co-gels reflect transition from series to parallel behavior with increasing collagen content. Journal of Biomechanical Engineering, 143:011004, 2012.[PubMed]
14. Matuszewski PE, Chen YL, Szczesny SE, Lake SP, Elliott DM, Soslowsky LJ, Dodge GR: Regional variation in human supraspinatus tendon proteoglycans: decorin, biglycan, and aggrecan. Connective Tissue Research, 53(5):343-348, 2012.[PubMed]
13. Lake SP, Cortes DH, Kadlowec JA, Soslowsky LJ, Elliott DM: Evaluation of affine fiber kinematics in human supraspinatus tendon using quantitative projection plot analysis. Biomechanics and Modeling in Mechanobiology, 11(1-2):197-205, 2012.[PubMed]
2011 & Prior
12. Raghupathy R, Witzenburg C, Lake SP, Sander EA, Barocas VH: Identification of regional mechanical anisotropy in soft tissue analogs. Journal of Biomechanical Engineering, 133:091011, 2011.[PubMed]
11. Lake SP, Hald ES, Barocas VH: Collagen-agarose co-gels as a model for collagen-matrix interaction in soft tissues subjected to indentation. Journal of Biomedical Materials Research: Part A, 99A(4):507-515, 2011.[PubMed]
10. Lake SP, Barocas VH: Mechanical and structural contribution of non-fibrillar extracellular matrix in uniaxial tension: a collagen-agarose co-gel model. Annals of Biomedical Engineering, 39(7):1891-1903, 2011. [PubMed]
9. Cortes DH, Lake SP, Kadlowec JA, Soslowsky LJ, Elliott DM: Characterizing the mechanical contribution of fiber angular distribution in connective tissue: comparison of two modeling approaches. Biomechanics and Modeling in Mechanobiology, 9(5):651-658, 2010. [PubMed]
8. Lake SP, Miller KS, Elliott DM, Soslowsky LJ: Tensile properties and fiber alignment of human supraspinatus tendon in the transverse direction demonstrate inhomogeneity, nonlinearity and regional isotropy. Journal of Biomechanics, 43(4):727-732, 2010.[PubMed]
7. Lake SP, Miller KS, Elliott DM, Soslowsky LJ: Effect of fiber distribution and realignment on the nonlinear and inhomogeneous mechanical properties of human supraspinatus tendon under longitudinal tensile loading. Journal of Orthopaedic Research, 27(12):1596-1602, 2009.[PubMed]
6. Lake SP, Ansorge HL, Soslowsky LJ: Animal models of tendinopathy. Disability and Rehabilitation, 30(20):1530-41, 2008. [PubMed]
5. Jelinsky SA, Lake SP, Archambault JM, Soslowsky LJ: Gene expression in rat supraspinatus tendon recovers from overuse with rest. Clinical Orthopaedics and Related Research, 466(7):1612-7, 2008. [PubMed]
4. Archambault JM, Jelinsky SA, Lake SP, Hill AA, Glaser DL, Soslowsky LJ: Rat supraspinatus tendon expresses cartilage markers with overuse. Journal of Orthopaedic Research, 25(5):617-624, 2007. [PubMed]
3. Gimbel JA, Van Kleunan JP, Lake SP, Williams GR, Soslowsky LJ: The role of repair tension on tendon to bone healing in an animal model of chronic rotator cuff tears. Journal of Biomechanics, 40:561-568, 2007.[PubMed]
2. Lujan TJ, Lake SP, Plaizier TA, Ellis BJ, Weiss JA: Simultaneous measurement of the three-dimensional joint kinematics and tissue strains with optical methods. Journal of Biomechanical Engineering, 127:193-197, 2005. [PubMed]
1. Bonifasi-Lista C, Lake SP, Small M, Weiss JA: Ligament multiaxial viscoelastic behavior under cyclic loading conditions. Journal of Orthopedic Research, 23:67-76, 2005. [PubMed]
Book Chapters
Zellers JA, Eekhoff JD, Tang SY, Hastings MK, Lake SP: Clinical complications of tendon tissue mechanics due to collagen cross-linking in diabetes, in The Science, Etiology and Mechanobiology of Diabetes and Its Complications, Edited by A. Gefen, 2021. [Link to Book]
Lake SP, Liu Q, Malcolm X, Iannucci LE, Wang Z, Zhao C: Tendon and Ligament Tissue Engineering, in Principles of Tissue Engineering, Edited by R. Lanza, R. Langer, J. Vacanti. [Link to Book]
Deeken CR, Lake SP: Hernia Materials – Fundamentals of Prosthetic Characteristics, in The SAGES Manual of Hernia Surgery, Edited by S. Davis, G. Dakin, A. Bates, by Springer Science, 2019. [Link to Book]
Conference Abstracts
Vaidya RS, Gilmore RE, Lohse K, Backup J, Lake SP, Guilak F, Zellers JA: Proteomics reveal region-specific and inter-individual variability in human Achilles tendons: a pilot study. 70th Annual Orthopaedic Research Society Meeting, 2024.
Scholp AJ, Fowler TP, Petersen E, Fredericks D, Salem AK, Coleman M, Lake SP, Martin JA, Sander EA: Blebbistatin as a method to improve outcomes following joint capsule release surgery in a rat model. 70th Annual Orthopaedic Research Society Meeting, 2024.
Reals RF, Castile RM, Bradley E, Movva A, Hu A, Hoopes CL, Chamberlain AM, Zmistowski BM, Lake SP: Anti-inflammatory treatment and active physical therapy have differing effects on functional and mechanical properties in a rat model of post-traumatic elbow contracture. 70th Annual Orthopaedic Research Society Meeting, 2024.
Reals RF, Castile RM, Snider JC, Chamberlain AM, Bersi MR, Lake SP: T cell populations are upregulated soon after injury in a rat model of post-traumatic joint contracture. MRC Symposium, St. Louis, MO, 2023.
Pavey SH, Eekhoff JD, Wagenseil JE, Lake SP: The role of fascicular elastin in functionally distinct tendons via a novel murine model of elastin knockdown. MRC Symposium, St. Louis, MO, 2023.
Cafiero M, Lake SP, David MA: Automating collagen gel image segmentation using Detectron2: an application of modern computer vision techniques. SB3C, Vail, CO, 2023.
David MA, Lake SP: Histopathology of capsule and cartilage predict elbow biomechanics via machine learning. SB3C, Vail, CO, 2023.
Pavey SH, Eekhoff JD, Wagenseil JE, Lake SP: Examining the role of elastin in functionally distinct tendons via a novel mouse model of elastin knockdown. 69th Annual Orthopaedic Research Society Meeting, Dallas, TX, 2023.
David MA, Yuan Y, Bacon A, Shah S, Movva A, Lang B, Gan W, Berke I, Kamilov U, Lake SP: Machine learning approaches to segment and cluster cells of the cartilage and capsule in rat elbow histology sections. OARSI World Congress on Osteoarthritis, Denver, CO, 2023.
David MA, James T, Reals RF, Quirk J, Gan W, Castile RM, Chamberlain AM, Kamilov U, Lake SP: Machine learning pipeline for analyzing magnetic resonance images of healthy and contracted joint capsules. 69th Annual Orthopaedic Research Society Meeting, Dallas, TX, 2023.
Iannucci LE, Lake SP: Dynamic assessment of progressive tendon degeneration using reflectance- or transmission-based quantitative polarized light imaging. 69th Annual Orthopaedic Research Society Meeting, Dallas, TX, 2023.
Reals RF, Castile RM, Snider JC, Chamberlain AM, Bersi MR, Lake SP: T cell populations are upregulated soon after injury in a rat model of post-traumatic joint contracture. 69th Annual Orthopaedic Research Society Meeting, Dallas, TX, 2023.
Reals RF, David MA, Iannucci LE, Lake SP: Simvastatin and zoledronic acid inhibit contraction in collagen gel model of fibrotic tissue contracture. 69th Annual Orthopaedic Research Society Meeting, Dallas, TX, 2023.
David MA, Yuan Y, Bacon A, Shah S, Movva A, Lang B, Gan W, Berke I, Kamilov U, Lake SP: Machine learning approaches to automatically segment and cluster cells in cartilage and capsule in digital histology sections. 4th Annual CU Orthopedic Research Symposium & D’Ambrosia Diversity Lectureship, Denver, CO, 2022.
Pavey SN, Eekhoff JD, Lake SP: Identifying the role of fascicular elastin in tendons using murine knockout models. CRM-MRC Musculoskeletal Biology & Regeneration Meeting, St. Louis, MO, 2022.
Iannucci LE, Lake SP: Reflectance quantitative polarized light imaging for dynamic microstructural analysis of orthopaedic soft tissues. CRM-MRC Musculoskeletal Biology & Regeneration Meeting, St. Louis, MO, 2022.
Shah S, David MA, Lang B, Bradley E, Movva A, Bacon A, Lake SP: Developing an automated image analysis program to evaluate elbow contracture using deep learning algorithms. CRM-MRC Musculoskeletal Biology & Regeneration Meeting, St. Louis, MO, 2022.
Eekhoff JD, Zellers JA, Cannon PC, Lake SP: Elastic fiber content and distribution in tendon varies by tendon type and tendon compartment. ORS Tendon Section Conference: Guiding the Future, Philadelphia, PA, 2022.
Eekhoff JD, Abraham J, Schott H, Solon L, Ulloa G, Cannon PC, Lake SP: Elastin contributes to the tensile instantaneous elastic stress response and viscoelastic properties of tendon fascicles. ORS Tendon Section Conference: Guiding the Future, Philadelphia, PA, 2022.
Eekhoff JD, Abraham J, Schott H, Solon L, Ulloa G, Cannon PC, Lake SP: Elastin contributes to the tensile instantaneous elastic stress response and viscoelastic properties of tendon fascicles. World Congress of Biomechanics, Taipei, Taiwan, 2022.
Iannucci LE, Riak ME, Lake SP: Non-anisotropic extracellular matrix properties’ effect on polarized light-based analysis of collagen fiber alignment in soft tissues. SPIE-West, 2022.
Iannucci LE, Riak M, Lake SP: Tendon-related extracellular matrix properties’ effect on polarized light-based analysis of collagen alignment. 68th Annual Orthopaedic Research Society Meeting, Tampa, FL, 2022.
Reiter AJ, Schott HR, Castile RM, Cannon PC, Havlioglu N, Chamberlain AM, Lake SP: Early joint use following elbow dislocation prevents post-traumatic joint contracture in a rat model. 68th Annual Orthopaedic Research Society Meeting, Tampa, FL, 2022.
Eekhoff JD, Zellers JA, Lake SP: Elastic fiber content and distribution in human tendon varies by tendon type and tendon compartment. 68th Annual Orthopaedic Research Society Meeting, Tampa, FL, 2022.
David MA, Bacon A, Yuan Y, Shah S, Movva A, Gan W, Berke I, Kamilov U, Lake SP: Machine learning approaches to probe novel multi-level relationships in post-traumatic joint contracture. 68th Annual Orthopaedic Research Society Meeting, Tampa, FL, 2022.
Iannucci LE, Riak ME, Lake SP: Non-anisotropic extracellular matrix properties’ effect on polarized light-based analysis of collagen fiber alignment in soft tissues. SPIE-West, 2022.
Eekhoff JD, Abraham J, Schott H, Solon L, Ulloa G, Cannon PC, Lake SP: Elastin contributes to the tensile instantaneous elastic stress response and viscoelastic properties of tendon fascicles. World Congress of Biomechanics, Taipei, Taiwan, 2022.
Brogan D, Obiofuma C, Lake SP, Iannucci LE, Dy C: Calculation of strain in the median nerve with increasing distal radius fracture displacement. American Association for Hand Surgery Annual Meeting, Carlsbad, CA, 2022.
Iannucci LE, Chen Y, Gruev V, Lake SP: Signal to noise ratio of polarization imaging parameters is dependent on light intensity and microstructural anisotropy of soft tissues. SB3C, Virtual, 2021.
Chang P, Solon LF, Castile RM, Hill JR, Lake SP, Brophy RH: Mechanical and microstructural properties of the anterior and posterior meniscal roots. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
Zellers JA, Edalati M, Tang SY, Lake SP, Eekhoff JD, Walk R, Zheng J, Hastings MK: Diffusion tensor imaging reveals collagen content and organization in ex vivo human Achilles tendon. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
Zellers JA, Eekhoff JD, Walk R, Hastings MK, Tang SY, Lake SP: Collagen organization – but not glycation state – predicts mechanical behavior in human Achilles tendon. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
Reiter AJ, Castile RM, Schott HR, Chamberlain AM, Lake SP: Early joint use preserves range-of-motion in a rat model of post-traumatic elbow contracture. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
Eekhoff JD, Abraham JA, Lake SP: Elastase treatment differentially affects murine Achilles and tibialis anterior tendon mechanics. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
David MA, Reiter AJ, Dunham CL, Castile RM, Havlioglu N, Chamberlain AM, Lake SP: Effects of simvastatin and losartan in a rat injury model of post-traumatic elbow contracture. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
Castile RM, Cannon PC, Smith MV, Brophy RH, Lake SP: Donor age and sex have a limited effect on mechanical and microstructural properties of connective tissues. 67th Annual Orthopaedic Research Society Meeting, Virtual, 2021.
Zellers JA, Zheng J, Youmans N, Tang SY, Lake SP, Mueller MJ, Hastings MK: Tendon changes with glycation on quantitative magnetic resonance imaging. APTA Combined Section Meeting, Orlando, FL, 2021.
Iannucci L, Gruev V, Lake SP: Comparison of transmission and reflectance quantitative polarized light imaging for collagen microstructure analysis of engineered soft tissue analogs. SPIE Photonics West, San Francisco, CA, 2021.
David MA, Reiter AJ, Dunham CL, Castile RM, Havlioglu N, Chamberlain AM, Lake SP: Simvastatin and losartan modify disease progression in a rat model of post-traumatic elbow contracture. Biomedical Engineering Society Meeting, San Diego, CA, 2020.
Guo J, Simmons DW, Munsell MK, Oguntuyo K, Kandalaft B, Rios B, Pear M, Schuftan D, Lake SP, Huebsch N: Elastomer grafted iPSC-derived micro heart muscles to investigate effects of mechanical loading on physiology. Biomedical Engineering Society Meeting, San Diego, CA, 2020.
Solon LF, Castile RM, Smith MV, Lake SP: Mechanical properties and microstructural alignment of the palmaris longus and gracilis tendons during dynamic loading. SB3C, Vail, CO, 2020.
Schott HR, Reiter AJ, Castile RM, Chamberlain AM, Lake SP: Quantification of heterotopic ossification in a rat elbow model of post-traumatic joint contracture. SB3C, Vail, CO, 2020.
Iannucci L, Stranne EE, Lake SP: Use of reflected quantitative polarized light imaging in detection of progressive microstructural changes in biologically degraded tendon. SB3C, Vail, CO, 2020.
David MA, Abraham JA, Iannucci LE, Shah I, Lake SP: Simvastatin, but not losartan, reduces cell contraction and viability in fibroblast-seeded collagen gels. SB3C, Vail, CO, 2020.
Eekhoff JD, Steenbock H, Brinckmann J, Lake SP: Malformed elastic fibers induce a tendon-specific increase in elastic modulus in fibulin-5 knockout mice. SB3C, Vail, CO, 2020.
Reiter AJ, Castile RM, Schott HR, Kivitz RJ, Chamberlain AM, Lake SP: Early, unrestricted motion is essential to preventing post-traumatic joint contracture in a rat elbow model. SB3C, Vail, CO, 2020.
Iannucci LE, Lake SP: Evaluation of collagen cross linking on quantitative polarized light imaging signal of soft tissue analogs. 66th Annual Orthopaedic Research Society Meeting, Phoenix, AZ, 2020
Dunham CL, Steenbock H, Brinckmann J, Reiter AJ, Castile RM, Chamberlain AM, Lake SP: Increased tissue volume and collagen crosslinks drive lateral collateral ligament contribution to post-traumatic elbow contracture in a rat model. 66th Annual Orthopaedic Research Society Meeting, Phoenix, AZ, 2020.
David MA, Abraham JA, Chamberlain AM, Lake SP: Simvastatin, but not losartan, dose-dependently inhibits gel contraction and reduces viability of NIH3T3 and human elbow capsule cells in vitro. CEMB 2nd Annual Meeting, St. Louis, MO, 2019.
Zellars JA, Eekhoff JD, Walk R, Tang SY, Hastings MK, Lake SP: Accumulation of advanced glycation end-products impairs hysteresis in human posterior tibialis tendon. 66th Annual Orthopaedic Research Society Meeting, Phoenix, AZ, 2020.
David MA, Abraham JA, Chamberlain AM, Lake SP: Simvastatin, but not losartan, dose-dependently inhibits gel contraction and reduces viability of NIH3T3 and human elbow capsule cells in vitro. 66th Annual Orthopaedic Research Society Meeting, Phoenix, AZ, 2020.
Reiter AJ, Castile RM, Chamberlain AM, Lake SP: Joint Function and Mechanics are Similar for Female and Male Rats in a Model of Post-traumatic Elbow Contracture. 66th Annual Orthopaedic Research Society Meeting, Phoenix, AZ, 2020.
Zellers JA, Eekhoff JD, Walk RE, Tang SY, Hastings MK, Lake SP: Relationship of advanced glycation end-product accumulation with posterior tibias tendon mechanics. American Physical Therapy Association Combined Sections Meeting 2020. Denver, CO.
Castile RM, Jenkins MJ, Lake SP, Brophy RH: Microstructural and mechanical properties of grafts commonly used for cruciate ligament reconstruction. AOSSM Annual Meeting, 2020.
Patel RM, Castile RM, Jenkins MJ, Lake SP, Brophy RH: Microstructural and mechanical properties of the anterolateral ligament (ALL) of the knee. AOSSM Annual Meeting, 2020.
Eekhoff JD, Lake SP: Functional elastic fibers are necessary for mechanical integrity of tendon: insights from haploinsufficient and fibulin-5 knockout murine models. Gordon Research Conference – Elastin, Elastic Fibers and Microfibrils, 2019.
Iannucci LE, Lake SP: Quantitative polarized light imaging signal is influenced by photon flux in both reflectance and transmission modes. 56th Annual Technical Meeting of the Society of Engineering Science. St. Louis, MO, 2019.
Abraham J, Eekhoff JD, Lake SP: Elastase Treatment Increases and Accelerates Stress Relaxation in Tendon. Summer Biomechanics, Bioengineering and Biotransport Conference, Seven Springs, PA, 2019.
Eekhoff JD, Lake SP: Comparative biomechanics across the hierarchical length scales of tendon. ISB/ASB, Calgary, CN, 2019.
Lake SP, Stoikes NFN, Badhwar A, Deeken CR: Contamination of hybrid hernia meshes compared to bioresorbable PhasixTM Mesh in a rabbit subcutaneous implant infection model. Hernia Surgery Summit, Park City, UT, 2019.
Eekhoff JD, Lake SP: Dysregulated elastic fiber assembly alters tendon mechanics in fibulin-5 knockout mice. 9th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2019.
Iannucci LE, Seidner MR, King NO, Gruev V, Lake SP: Development of a reflected quantitative polarized light imaging technique: microstructural analysis of soft tissue analogs. 9th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2019.
Reiter AJ, Kivitz GJ, Castile RM, Cannon PJ, Lakes EH, Jacobs BY, Allen KD, Chamberlain AM, Lake SP: Functional measures of grip strength and gait remain altered long-term in a rat model of post-traumatic elbow contracture. 9th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2019.
Eekhoff JD, Lake SP: Dysregulated elastic fiber assembly alters tendon mechanics in fibulin-5 knockout mice. 65th Annual Orthopaedic Research Society Meeting, Austin, TX, 2019.
Iannucci LE, Seidner MR, Lake SP: Development of a reflected quantitative polarized light imaging technique: microstructural analysis of soft tissue analogs. 65th Annual Orthopaedic Research Society Meeting, Austin, TX, 2019.
Castile RM, Smith MV, Brophy RH, Lake SP: Mechanical and microstructural properties of the quadriceps tendon compared to other common grafts used for ACL reconstruction. 65th Annual Orthopaedic Research Society Meeting, Austin, TX, 2019.
Reiter AJ, Kivitz GJ, Castile RM, Cannon PJ, Lakes EH, Jacobs BY, Allen KD, Chamberlain AM, Lake SP: Rat model of elbow joint contracture shows long-term gait compensations and grip strength reductions. 65th Annual Orthopaedic Research Society Meeting, Austin, TX, 2019.
Patel RM, Jenkins MJ, Castile RM, Lake SP, Brophy BH: Microstructural and mechanical properties of the anterolateral knee capsule complex. 65th Annual Orthopaedic Research Society Meeting, Austin, TX, 2019.
Eekhoff JD, Lake SP: Dysregulated elastic fiber assembly alters tendon mechanics in fibulin-5 knockout mice. ORS Tendon Section Conference, Portland, OR, 2018.
Owen GS, Reiter AJ, Castile RM, Chamberlain AM, Lake SP: Traumatic elbow injury in a rat model causes morphological changes in bone microstructure. Biomedical Engineering Society Meeting, Atlanta, GA, 2018.
Reiter AJ, Kivitz GJ, Castile RM, Lakes EH, Jacobs BY, Allen KD, Chamberlain AM, Lake SP: Unilateral injury in a rat model of elbow joint contracture leads to long-term functional deficits. Gordon Research Conference, 2018.
Dunham CL, Meyer GA, Lake SP: Mechanical priming to direct adipose progenitor cells toward an anti-fibrotic phenotype as a therapy to prevent post-traumatic elbow contracture in a rat model. Gordon Research Conference, 2018.
Reiter AJ, Kivitz GJ, Castile RM, Lakes EH, Allen KD, Chamberlain AM, Lake SP: Spatiotemporal gait compensation due to unilateral forelimb injury in a rat model of elbow contracture. 8th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2018.
Eekhoff JD, Fang F, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP: Elastin contributes to stiffness and structural reorganization in functionally distinct mouse tendons. 8th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2018.
Dunham CL, Castile RM, Chamberlain AM, Meyer GA, Lake SP: Persistent motion loss caused primarily by arthrogenic tissue in a rat model of post-traumatic elbow contracture. 8th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2018.
Eekhoff JD, Lake SP: Elastin quantity in tendon is dependent on species and specific tendon function. 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
Castile RM, Jenkins MJ, Smith MV, Brophy RH, Lake SP: Mechanical properties and microstructural realignment differences between patellar and semitendinosus grafts used for ligament reconstruction. 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
Reiter AJ, Kivitz GJ, Castile RM, Chamberlain AM, Lake SP: Active physical therapy reduces post-traumatic joint contracture in a rat elbow model. 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
Fang F, Lake SP: Composition-dependent mechanisms of multiscale tendon mechanics. 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
Castile RM, Jenkins MJ, Smith MV, Lake SP: Microstructural properties of the ulnar collateral ligament are bundle specific and align with differences in mechanical properties. 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
Dunham CL, Castile RM, Chamberlain AM, Meyer GA, Lake SP: Persistent motion loss caused primarily by arthrogenic rather than myogenic tissues in a rat model of post-traumatic elbow joint contracture. 8th World Congress of Biomechanics, Dublin, Ireland, 2018.
Reiter AJ, Kivitz GJ, Castile RM, Lakes EH, Allen KD, Chamberlain AM, Lake SP: Spatiotemporal gait compensation due to unilateral forelimb injury in a rat model of elbow contracture. 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2018.
Fang F, Lake SP: Correlation of enzymatic collagen crosslinking and multiscale tendon mechanics. 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2018.
Dunham CL, Chamberlain AM, Galatz, LM, Lake SP: Muscle genetic expression supports its limited mechanical contribution to elbow joint contracture. 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2018.
Dunham CL, Castile RM, Chamberlain AM, Lake SP: Persistent motion loss due to irreversible mechanical changes in the anterior capsule of a rat model of elbow post-traumatic joint contracture. 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2018.
Eekhoff JD, Fang F, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP: Elastin contributes to stiffness and structural reorganization in functionally distinct mouse tendons. 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2018.
Kivitz GJ, Reiter AJ, Castile RM, Andres P, Dunham CL, Chamberlain AM, Lake SP: Design and use of a bilateral grip strength device for assessing forelimb function in rodents. Biomedical Engineering Society Meeting, Phoenix, AZ, 2017.
Reiter AJ, Dunham CL, Castile RM, Chamberlain AM, Galatz LM, Lake SP: Biological intervention to reduce post-traumatic joint contracture: preliminary evidence supporting the use of simvastatin or losartan. Summer Biomechanics, Bioengineering and Biotransport Conference, Tucson, AZ, 2017.
Dunham CL, Castile RM, Chamberlain AM, Lake SP: Anterior capsule is a larger contributor to contracture than muscle in a rat elbow model of post-traumatic joint contracture. Summer Biomechanics, Bioengineering and Biotransport Conference, Tucson, AZ, 2017.
Reiter AJ, Dunham CL, Castile RM, Chamberlain AM, Galatz LM, Lake SP: Biological intervention to reduce post-traumatic joint contracture: preliminary evidence supporting the use of simvastatin or losartan. Musculoskeletal Regenerative Medicine and Biology: From Development to Regeneration, St. Louis, MO, 2017.
Dunham CL, Castile RM, Havlioglu N, Chamberlain AM, Galatz LM, Lake SP: Short-term time course of contracture development in a rat elbow model of post-traumatic joint contracture. Musculoskeletal Regenerative Medicine and Biology: From Development to Regeneration, St. Louis, MO, 2017.
Fang F, Lake SP: Region-dependent distribution of elastic fibers in genetically-modified mouse supraspinatus and Achilles tendons. Musculoskeletal Regenerative Medicine and Biology: From Development to Regeneration, St. Louis, MO, 2017.
Kahan LG, Brunt LM, Lake SP, Tan WH, McAllister J, Yu J, Thompson Jr DM, Blatnik JA: Evaluating mechanical integration at the mesh-tissue interface in ventral hernia repair. SAGES Annual Meeting, Houston, TX, 2017.
Smith MV, Castile RM, Bernholt D, Brophy RH, Lake SP: Bundle-Specific Mechanics and Real-Time Microstructural Changes of the Ulnar Collateral Ligament under Load. AOA Annual Leadership Meeting, Charlotte, NC, 2017.
Castile RM, Skelley NW, Brophy RH, Lake SP: Mechanical and microstructural properties of common graft options for knee ligament reconstruction. 63rd Annual Orthopaedic Research Society Meeting, San Diego, CA, 2017.
Smith MV, Castile RM, Dewan A, Bernholt D, Brophy RH, Lake SP: Bundle-specific mechanics and real-time microstructural changes of the ulnar collateral ligament under load. 63rd Annual Orthopaedic Research Society Meeting, San Diego, CA, 2017.
Dunham CL, Chamberlain AM, Galatz LM, Meyer GA, Lake SP: Active and passive muscle mechanics are altered in a rat elbow model of post-traumatic joint contracture. 63rd Annual Orthopaedic Research Society Meeting, San Diego, CA, 2017.
Dunham CL, Castile RM, Havlioglu N, Chamberlain AM, Galatz LM, Lake SP: Short-term time course of contracture development in a rat elbow model of post-traumatic joint contracture. 63rd Annual Orthopaedic Research Society Meeting, San Diego, CA, 2017.
Fang F, Lake SP: Region-dependent distribution of elastic fibers in genetically-modified mouse supraspinatus and Achilles tendons. 63rd Annual Orthopaedic Research Society Meeting, San Diego, CA, 2017.
Nedrelow DS, Lai VK, Lake SP, Kim B, Weiss EM, Tranquillo RT, Barocas VH: Swelling of collagen-hyaluronic acid co-gels: an in vitro residual stress model. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016.
Castile RM, Skelley NW, Wright JO, Brophy RH, Lake SP: Differences between the mechanical and microstructural properties of the human ACL and PCL. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016.
Dunham CL, Castile RM, Galatz LM, Lake SP: Alterations in the anterior capsule correlate with impaired joint mechanics in a rat elbow model of post-traumatic joint stiffness. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016.
Est SE, Roen ME, Chi VT, Simien AP, Castile RM, Thompson DM, Deeken CR, Lake SP: Off-axis biaxial analysis of synthetic scaffolds for hernia repair. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016.
Fang F, Lake SP: Multiscale mechanics of human supraspinatus tendon in shear after proteoglycan depletion. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016.
Fang F, Espinosa MG, Kahan L, Mecham RP, Lake SP: Altered mechanics of supraspinatus tendons from elastin-deficient genetically-modified mice. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016.
Castile RM, Wright JO, Schur RP, Skelley NW, Brophy RH, Lake SP: The two bundles of the PCL exhibit similar microstructural and mechanical properties. 6th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2016.
Castile RM, Skelley NW, Weber CI, Brophy RH, Lake SP: Mechanical and microstructural properties of the human ACL follow a linear gradient through region-specific analysis. 6th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2016.
Dunham CL, Castile RM, Galatz LM, Lake SP: Pronation-supination motion is significantly decreased in a rat model of post-traumatic elbow stiffness. 6th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2016.
Wright JO, Schur R, Castile RM, Skelley NW, Brophy RH, Lake SP: Anterolateral and posteromedial bundles of the PCL exhibit similar microstructural and mechanical properties. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, 2016.
Fang F, Lake SP: The contribution of elastin to the region-specific multiscale mechanics of human supraspinatus tendon in shear. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, 2016.
Castile RM, Skelley NW, Weber C, Brophy RH, Lake SP: Region-specific mechanical and microstructural properties of the human ACL follow a linear gradient. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, 2016.
Dunham CL, Castile RM, Galatz LM, Lake SP: Pronation-supination motion is significantly decreased in a rat model of post-traumatic elbow stiffness. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, 2016.
Shah N, Filas BA, Lake SP, Beebe DC: Mechanically-induced fiber remodeling in the vitreous body. Biomedical Engineering Society Meeting, Tampa, FL, 2015.
Fang F, Lake SP: Composition-dependent mechanical properties and multiscale strain transfer in tendon subjected to shear loading. Summer Biomechanics, Bioengineering and Biotransport Conference, Snowbird Resort, Utah, 2015.
Castile RM, Skelley NW, Brophy RH, Lake SP: Two bundles of the anterior cruciate ligament exhibit different microstructural properties and mechanics during stress-relaxation. Summer Biomechanics, Bioengineering and Biotransport Conference, Snowbird Resort, Utah, 2015.
Castile RM, Galatz LM, Lake SP: Altered joint motion persists following remobilization in an animal model of post-traumatic elbow contracture. 5th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2015.
Castile RM, Skelley NW, York TE, Gruev V, Brophy RH, Lake SP: Two bundles of the anterior cruciate ligament exhibit different microstructural and material properties. 5th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2015.
Fang F, Lake SP: Multiscale strain evaluation of tendon under compressive loading. 5th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2015.
Espinosa MG, Wu Q, Fang F, Stoilov I, Mecham RP, Lake SP: Elastin deficiency corresponds to reduction in tendon mechanics. 5th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2015.
Ray S, Zihni AM, Thompson Jr DM, Gluckstein J, Lake SP, Deeken CR: Effect of mesh density and pore size/shape on tissue ingrowth in a porcine model of incisional hernia repair. World Hernia Congress, Milan, Italy, 2015.
Skelley NW, Castile RM, York TE, Gruev V, Brophy RH, Lake SP: Anteromedial and posterolateral bundles of the anterior cruciate ligament exhibit different microstructural and material properties. Mid-America Orthopaedic Association Annual Meeting, Hilton Head, SC, 2015.
Fang F, Sawhney AS, Lake SP: Multiscale analysis of tendon subjected to shear and compression demonstrates strain attenuation, uncrimping and sliding. 61st Annual Orthopaedic Research Society Meeting, Las Vegas, NV, 2015.
Castile RM, Galatz LM, Lake SP: Joint motion remains altered following remobilization in an animal model of post-traumatic elbow contracture. 61st Annual Orthopaedic Research Society Meeting, Las Vegas, NV, 2015.
Skelley NW, Castile RM, York TE, Gruev V, Brophy RH, Lake SP: Anteromedial and posterolateral bundles of the anterior cruciate ligament exhibit different microstructural and material properties. 61st Annual Orthopaedic Research Society Meeting, Las Vegas, NV, 2015.
Kahan L, Lake SP: Development of a device to non-invasively induce osteoarthritis of the elbow in an animal model. Biomedical Engineering Society Meeting, San Antonio, TX, 2014.
Liu MC, Castile RM, Galatz LM, Lake SP: Altered trabecular bone in an animal model of post-traumatic elbow stiffness. Biomedical Engineering Society Meeting, San Antonio, TX, 2014.
Deeken CR, Thompson Jr. DM, Castile RM, Lake SP: Biaxial analysis of synthetic scaffolds for hernia repair demonstrates variability in mechanical anisotropy, non-linearity and hysteresis. Biomedical Engineering Society Meeting, San Antonio, TX, 2014.
Espinosa MG, Wu Q, Stoilov I, Mecham R, Lake SP: Elastin deficiency corresponds to a dose-dependent reduction in tendon mechanics. Biomedical Engineering Society Meeting, San Antonio, TX, 2014.
Filas BA, Shah N, Zhang Q, Shui YB, Lake SP, and Beebe DC. Biomechanical Effects of Proteoglycan Degradation on Vitreous and Vitreoretinal Structure. 13th Congress of the International Society of Ocular Toxicology. October 2014, Kanazawa, Japan.
Lake SP, Castile RM, Kormpakis I, Galatz LM, van Riet R: Comparison of unicortical versus bicortical distal biceps tendon fixation strength using a metallic button. 25th Annual Congress of SECEC, Istanbul, Turkey, 2014.
Wu Q, Stoilov I, Mecham RP, Lake SP: Elastin reduction impairs the mechanical properties of supraspinatus tendon. 7th World Congress of Biomechanics, Boston, MA, 2014.
Castile RM, Galatz LM, Lake SP: Development of an animal model of post-traumatic stiffness and joint contracture of the elbow. 7th World Congress of Biomechanics, Boston, MA, 2014.
Fang F, Sawhney A, Lake SP: The macroscale and microscale response of tendon to shear. 7th World Congress of Biomechanics, Boston, MA, 2014.
Lake SP, Zhang L, Lai VK, Picu CP, Shephard MS, Barocas VH: Microstructural mechanical models of fiber-matrix interaction in soft tissues. 7th World Congress of Biomechanics, Boston, MA, 2014.
Zitnay JL, Lake SP, Quinn KP, Lee DJ, Winkelstein BA, Barocas VH: Multiscale modeling of the cervical facet capsular ligament during tensile joint loading. 7th World Congress of Biomechanics, Boston, MA, 2014.
Castile RM, Galatz LM, Lake SP: Development of an animal model of post-traumatic stiffness and joint contracture of the elbow. 4th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2014.
Fang F, Sawhney A, Lake SP: The macroscale and microscale response of tendon to shear. 4th Annual Winter Symposium, Musculoskeletal Research Center, Washington University, 2014.
Castile RM, Borinsky S, Walter CM, Galatz LM, Lake SP: Development of an animal model of post-traumatic stiffness and joint contracture of the elbow. 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2014.
Fang F, Lake SP: Multiscale strain transfer in tendon under compressive load. 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2014.
Lai VK, Lake SP, Kim B, Weiss EM, Tranquillo RT, Barocas VH: Swelling of collagen-hyaluronic acid tissue-equivalents: an experimental model to evaluate residual stress in soft tissues. ASME Summer Bioengineering Conference, Sunriver, OR, 2013.
Lake SP, Zhang L, Lai VK, Picu CP, Shephard MS, Barocas VH: Microstructural mechanical models of fiber-matrix interaction in soft tissues: comparison of parallel and coupled approaches. 59th Annual Orthopaedic Research Society Meeting, San Antonio, TX, 2013.
Lai VK, Lake SP, Tranquillo RT, Barocas VH: Multiscale approach to modeling the passive mechanics of cells in tissues. Institute for Engineering and Medicine Innovation Showcase, Minneapolis, MN, 2012.
Montaniel KRC, Adhikari N, Lake SP, Billaud M, Carlson M, Isakson BE, Barocas VH, Hall JL: Smooth muscle specific deletion of N-deacetylase-sulfontransferase1 (Ndst1) results in altered arterial elasticity. American Heart Association Meeting, Los Angeles, CA, 2012.
Lai VK, Lake SP, Tranquillo RT, Barocas VH: Multiscale approach to modeling the passive mechanics of cells in tissues. Biomedical Engineering Society Meeting, Atlanta, GA, 2012.
Lai VK, Kerandi AM, Lake SP, Tranquillo RT, Barocas VH: Collagen network architecture varies between pure collagen and collagen-fibrin co-gels. ASME Summer Bioengineering Conference, Fajardo, Puerto Rico, 2012.
Zhang L, Lake SP, Lai VK, Barocas VH, Shephard MS: Elucidation of microstructural interactions between collagen and non-fibrillar matrix in soft tissue using a coupled fiber-matrix model. ASME Summer Bioengineering Conference, Fajardo, Puerto Rico, 2012.
Lai VK, Frey C, Kerandi AM, Lake SP, Tranquillo RT, Barocas VH: Microstructural and mechanical differences between digested collagen-fibrin co-gels and pure collagen and fibrin gels. Industrial Partnership for Research in Interfacial and Materials Engineering (iPrime) Annual Meeting, Minneapolis, MN, 2012.
Matuszewski PE, Chen YL, Szczesny SE, Lake SP, Elliott DM, Soslowsky LJ, Dodge GR: Regional variations in proteoglycans decorin, biglycan, and aggrecan: implications to mechanical behavior of the supraspinatus tendon. American Academy of Orthopaedic Surgeons Meeting, San Francisco, CA, 2012.
Lake SP, Sheth PM, O’Neil AM, Raghupathy R, Barocas VH: Highly inhomogeneous spatial properties of human supraspinatus tendon quantified via biaxial mechanical testing and anisotropic inverse mechanics. 58th Annual Orthopaedic Research Society Meeting, San Francisco, CA, 2012.
Lake SP, Hadi MF, Barocas VH: A network-based microscale model of non-fibrillar matrix in soft tissue. LifeScience Alley 10th Annual Conference and Expo, Minneapolis, MN, 2011.
Zhang L, Delalondre F, Weissenstein E, Shephard MS, Hadi MF, Lai VK, Lake SP, Barocas VH: Parallel hierarchic multiscale simulation of bioengineering tissue. 11th US National Congress on Computational Mechanics, Minneapolis, MN, 2011.
Lake SP, Hadi MF, Barocas VH: Evaluation of the mechanical role of non-fibrillar matrix in collagen gel tissue analogs using a coupled fiber-matrix microscale model. Biomedical Engineering Society Meeting, Hartford, CT, 2011.
Raghupathy R, Lake SP, Sander EA, Witzenburg C, Barocas VH: Anisotropic inverse mechanics identifies regional changes in mechanical anisotropy during remodeling of fibroblast-populated collagen cruciforms. ASME Summer Bioengineering Conference, Farmington, PA, 2011.
Lai VK, Sander EA, Lake SP, Tranquillo RT, Barocas VH: Collagen network topology is influenced by collagen concentration, but not by presence of fibrin. ASME Summer Bioengineering Conference, Farmington, PA, 2011.
Lake SP, Barocas VH: Initial collagen fiber alignment determines the mechanical and structural response of cell-compacted tissue-equivalents under indentation. ASME Summer Bioengineering Conference, Farmington, PA, 2011.
Lake SP, Doggett S, Barocas VH: Collagen-agarose co-gels as a model for collagen-matrix interaction in soft tissue. ASME Summer Bioengineering Conference, Farmington, PA, 2011.
Matuszewski PE, Chen YL, Szczesny SE, Lake SP, Elliott DM, Soslowsky LJ, Dodge GR: Regional variations in proteoglycans decorin, biglycan, and aggrecan: implications to mechanical behavior of the supraspinatus tendon. 57th Annual Orthopaedic Research Society Meeting, Long Beach, CA, 2011.
Lake SP, Hald ES, Barocas VH: Mechanical and structural contribution of non-fibrillar matrix in a collagen-agarose co-gel model. 57th Annual Orthopaedic Research Society Meeting, Long Beach, CA, 2011.
Raghupathy R, Witzenburg CM, Lake SP, Thomas M, Barocas VH: Identification of regional mechanical anisotropy in soft tissues by generalized anisotropic inverse mechanics. LifeScience Alley 9th Annual Conference and Expo, Minneapolis, MN, 2010.
Raghupathy R, O’Brien CM, Oltean A, Lake SP, Barocas VH: Inverse mechanics of cardiovascular tissues. Biomedical Engineering Society Meeting,Austin, TX, 2010.
Lake SP, Barocas VH: Three-dimensional collagen fiber kinematics in collagen gels subjected to indentation. Biomedical Engineering Society Meeting,Austin, TX, 2010.
Lake SP, Miller KS, Elliott DM, Soslowsky LJ: Inhomogeneous multiaxial tensile properties, fiber alignment and realignment under load of human supraspinatus tendon. International Shoulder Group Conference,Minneapolis, MN, 2010.
Oltean A, Lake SP, Raghupathy R, O’Brien C, Barocas VH: Mechanical properties along the branching site of the abdominal aorta and iliac arteries. ASME Summer Bioengineering Conference, Naples, FL, 2010.
Dean RM, Sander EA, Lake SP, Barocas VH: The effects of biaxial preconditioning on acellular collagen gels. ASME Summer Bioengineering Conference, Naples, FL, 2010.
Raghupathy R, Lake SP, Sander EA, Barocas VH: Generalized anisotropic inverse mechanics: mechanical anisotropy correlates with structural anisotropy in collagen based tissue equivalents. ASME Summer Bioengineering Conference, Naples, FL, 2010.
Cortes DH, Lake SP, Kadlowec JA, Soslowsky LJ, Elliott DM: Mechanical contribution of fiber angular distribution in connective tissue: comparison of two modeling approaches. ASME Summer Bioengineering Conference,Naples, FL, 2010.
Lake SP, Cortes DH, Kadlowec JA, Elliot DM, Soslowsky LJ: Comparison of experimental and affine-predicted fiber kinematics in human supraspinatus tendon. ASME Summer Bioengineering Conference, Naples, FL, 2010.
Cortes DH, Lake SP, Kadlowec JA, Soslowsky LJ, Elliott DM: Evaluating human supraspinatus tendon structure-function relationships using a model of fiber crimp and angular distribution. 56th Annual Orthopaedic Research Society Meeting, New Orleans, LA, 2010.
Lake SP, Miller KS, Kadlowec JA, Elliott DM, Soslowsky LJ: Inhomogeneous and nonlinear transverse tensile properties and fiber alignment of human supraspinatus tendon. ASME Summer Bioengineering Conference, Lake Tahoe, CA, 2009.
Kadlowec JA, Lake SP, Miller KS, Soslowsky LJ, Elliott DM: A hyperelastic model with distributed fibers to describe human supraspinatus tendon tensile mechanics. ASME Summer Bioengineering Conference, Lake Tahoe, CA, 2009.
Lake SP, Miller KS, Soslowsky LJ, Elliott DM: Fiber re-alignment under load contributes to human supraspinatus tendon nonlinearity and inhomogeneity. 55th Annual Orthopaedic Society Meeting 34:1431, Las Vegas, NV, 2009.
Lake SP, Nerurkar NL, Mauck RL, Kadlowec JA, Elliott DM, Soslowsky LJ: Development of a nonlinear anisotropic fiber dispersion model to quantify and predict mechanics of normal and injured tendon. 54th Annual Orthopaedic Research Society Meeting 33:824, San Francisco, CA, 2008.
Jelinsky SA, Lake SP, Archambault JM, Wilson E, Hill A, Seeherman H, Wozney J, Soslowsky LJ: Gene expression in rat supraspinatus tendon recovers from overuse with rest. 53rd Annual Orthopaedic Research Society Meeting 32:362, San Diego, CA, 2007.
Archambault JM, Jelinsky SA, Lake SP, Saraf K, Hill A, Brown EL, Seeherman H, Wozney J, Soslowsky LJ: Rat supraspinatus tendon expresses cartilage markers with overuse. 52nd Annual Orthopaedic Research Society Meeting 31:35, Chicago, IL, 2006.
Perry SM, Lake SP, Soslowsky LJ: Extracellular matrix mRNA changes in an overuse rotator cuff animal model. 51st Annual Orthopaedic Research Society Meeting, 30:70, Washington, DC, 2005.
Lujan TJ, Dalton MS, Lake SP, Ellis BJ, Rosenberg TD, Weiss JA: ACL injury alters MCL strain during Anterior-Posterior but not Varus-Valgus loading. 50th Annual Orthopaedic Research Society Meeting, 29:1272, San Francisco, CA, 2004.
Bonifasi-Lista C, Lake SP, Small MS, Weiss JA: Multiaxial viscoelastic material properties of the human medial collateral ligament. 49th Annual Orthopaedic Research Society Meeting, 28:808, New Orleans, LA, 2003.
Bonifasi-Lista C, Lake SP, Small MS, Weiss JA: Viscoelastic properties of the human MCL in the transverse direction. ASME International Mechanical Engineering Congress and Exposition, New Orleans, LA, 2002.
Bonifasi-Lista C, Lake SP, Ellis BJ, Rosenberg TD, Weiss JA: Strain- and rate-dependent viscoelastic properties of human MCL in tension. 48th Annual Orthopaedic Research Society Meeting, 27:609, Dallas, TX, 2002.