Tendon is a highly aligned hierarchically structured tissue which plays a crucial role in the musculoskeletal system by transmitting forces from muscle to bone. Reorganization of this hierarchical collagenous structure with mechanical loading relates to strain attenuation in the tissue down decreasing length scales. We have explored these multiscale mechanisms in tendon subjected to compression and shear loading. In addition, we are investigating how potential linking components of the collagen network influence the mechanical response of tendon.
Multiscale evaluation of multi-axial loading in tendon
Contribution of elastic fibers to tendon mechanics
Linking Components in multiscale tendon mechanics
Collaborators
Dr. Robert Mecham – Cell Biology & Physiology, Washington University
Dr. Jessica Wagenseil – Mechanical Engineering & Materials Science, Washington University
Dr. Robert Brophy – Orthopaedic Surgery, Washington University